It's a collection of his work ranging from one-panel comic book takeoffs:
To recurring strips following the well-spoken title characters ("Hssssss." "Wipe me with a paper towel to remove excess grease."), Roger Daltry's sex blimp, Twain and Einstein at the planet's core, and a belligerent Pablo Picasso threatening to break adversaries "into the leetle cubes!":
He's released newer material as Tales Designed to Thrizzle from Fantagraphics, but Snake 'n Bacon is the true perfect nugget of unstoppable hilarity.